I. Information of ICE
ICEberg ID793
Name ICESagTR7 This ICE is derived from experimental literature
OrganismStreptococcus agalactiae SagTR7
Size (bp)~129 kb
GC content [Genome] (%)-
Insertion siterplL
FunctionA composite ICE containing IMESp2907 and ICESag37741(also a comosite ICE consist of ICESde37741 and a 52 kb component), the first ICESa2603 family element carrying and capable of transferring resistance determinants for both antibiotics (erythromycin) and heavy metals (cadmium and arsenic)
Species that ICE can be transferred toStreptococcus agalactiae 1357RF
Nucleotide SequenceKP898896 (partial ICE sequence)
Putative oriT region -
Putative relaxase coordinates: 6211..7851; Locus tag: -;  Family:  MOBQ

II. ICE interaction with IME/CIME/

The Interaction Network among ICE/IME/CIME

Detailed Informatioin of the Interaction Network
# ICE  Inter_Ele [Type] Methods Donors Recipients Exper_Ref 
1ICESagTR7 IMESp2907  [IME] experimentalin cis Streptococcus agalactiae SagTR7 Streptococcus agalactiae 1357RF 26679245

experimental This is an interactioin derived from experimental literature

The graph information of ICESagTR7 components from KP898896
Incomplete gene list of ICESagTR7 from KP898896
#Gene Coordinates [+/-], size (bp) Product 
(GenBank annotation)
1-1..103 [+], 103single-stranded DNA-binding protein
2-107..265 [+], 159conjugal transfer protein
3-383..601 [+], 219transcriptional regulator
4-605..982 [+], 378hypothetical protein
5-1370..1828 [+], 459MarR family protein
6-1818..3149 [+], 1332MATE-like superfamily protein
7-3226..3339 [+], 114hypothetical protein
8erm(TR)3831..4562 [+], 732erythromycin resistance methylaseAR 
9-4863..5303 [+], 441Spectinomycin phosphotransferase
10-5349..5489 [+], 141hypothetical protein
11-5547..5861 [+], 315hypothetical protein
12-6211..7851 [+], 1641MobA/MobL family proteinRelaxase, MOBQ Family
13-7925..8098 [+], 174hypothetical protein
14-8282..8809 [+], 528PF12687 domain protein
15-9012..10043 [+], 1032DUF1016 superfamily protein
16-10109..10837 [+], 729phage replisome organizer N-terminal domain protein
17-10992..11216 [+], 225hypothetical protein
18tndX11220..12866 [+], 1647Ser_recombinase superfamily proteinIntegrase 
19-13056..13213 [+], 158membrane protein
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer
virulence  Gene may be involved in adaptative function

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
(1) Morici E; Simoni S; Brenciani A; Giovanetti E; Varaldo PE; Mingoia M (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PudMed:27621174] experimental
(2) Mingoia M; Morici E; Marini E; Brenciani A; Giovanetti E; Varaldo PE (2016). Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907. J Antimicrob Chemother. 71(3):593-600. [PudMed:26679245] experimental
experimental experimental literature