ICEberg
I. Information of ICE
ICEberg ID791
Name ICESag37 This ICE is derived from experimental literature
FamilyICESa2603
OrganismStreptococcus agalactiae Sag37
Size (bp)73,429
GC content [Genome] (%)37.73
Insertion siterumA
FunctionAntibiotic resistance genes: erm(B), tet(O), sat4, aphA, ant(6)
Species that ICE can be transferred toStreptococcus agalactiae
Nucleotide SequenceCP019978 (complete ICE sequence in this genome)
Replicon-
Genome coordinates629058..702486 
Putative oriT region -
Putative relaxase coordinates: 690710..692593; Locus tag: B1H24_03875;  Family:  MOBP


II. ICE interaction with IME/CIME/

The interaction information of ICESag37 is not available.



The graph information of ICESag37 components from CP019978
Complete gene list of ICESag37 from CP019978
#Gene Coordinates [+/-], size (bp) Product 
(GenBank annotation)
*Reannotation 
1B1H24_03515624419..625702 [+], 12843-phosphoshikimate 1-carboxyvinyltransferase
2B1H24_03520625695..626207 [+], 513shikimate kinase
3B1H24_03525626264..627637 [+], 1374LytR family transcriptional regulator
4B1H24_03530627738..629099 [+], 136223S rRNA (uracil-5-)-methyltransferase RumA
5B1H24_03535629310..629483 [+], 174hypothetical protein
6B1H24_03540629480..630298 [+], 819replication initiator protein
7B1H24_03545630300..630395 [+], 96hypothetical protein
8B1H24_03550630447..631802 [+], 1356DNA (cytosine-5-)-methyltransferase
9B1H24_03555631786..632214 [+], 429hypothetical protein
10B1H24_03560632225..632608 [+], 384hypothetical protein
11B1H24_03565632617..632850 [+], 234transcriptional regulator
12B1H24_03570632853..633437 [+], 585CPBP family intramembrane metalloprotease
13B1H24_03575633515..634003 [+], 489hypothetical protein
14B1H24_03580634003..635820 [+], 1818type IV secretory pathway, VirD4 component
15B1H24_03585635838..636080 [+], 243hypothetical protein
16B1H24_03590636099..636953 [+], 855conjugal transfer protein TrbL
17B1H24_03595637015..637368 [+], 354PrgI family protein
18B1H24_03600637346..639676 [+], 2331type IV secretory pathway, VirB4 componentPrgJ, T4SS component 
19B1H24_03605639678..642479 [+], 2802transposasePrgK, T4SS component 
20B1H24_03610642542..643387 [-], 846abortive phage infection protein
21B1H24_03615643384..643974 [-], 591abortive phage infection protein
22B1H24_03620644144..649039 [+], 4896glucan-binding proteinPrgB, T4SS component 
23B1H24_03625649040..649231 [+], 192calcium-binding protein
24B1H24_03630649215..649766 [+], 552hypothetical protein
25B1H24_03635649816..655257 [+], 5442SNF2 family protein (disrupted by reverse transcriptase)
26B1H24_03640655755..657533 [+], 1779reverse transcriptase
27B1H24_03645657671..659014 [+], 1344SNF2 family protein (disrupted by reverse transcriptase)
28B1H24_03650659085..659384 [+], 300hypothetical protein
29B1H24_03655659398..659688 [+], 291hypothetical protein
30B1H24_03665660493..660867 [+], 375TnpV protein
31B1H24_03670661234..663153 [+], 1920tetracycline resistance ribosomal protection protein Tet(O)AR 
32B1H24_03675663205..663378 [+], 174conjugal transfer protein
33B1H24_03685664384..665076 [+], 693topoisomerase I
34B1H24_03690665573..665869 [+], 297DNA recombinase
35B1H24_03695665870..666286 [+], 417recombinase
36B1H24_03700666306..667850 [+], 1545recombinase family proteinIntegrase 
37B1H24_03705667993..668217 [+], 225transcriptional regulator
38B1H24_03710668232..669101 [+], 870hypothetical protein
39B1H24_03715669082..669816 [+], 735methyltransferase
40B1H24_03720669849..670757 [+], 909aminoglycoside nucleotidyltransferase ANT(6)-Ia
41B1H24_03735672349..672606 [+], 258streptothricin acetyltransferase, sat4 (disrupted by ISSag12)
42B1H24_03740672699..673493 [+], 795aminoglycoside O-phosphotransferase APH(3')-IIIaAR 
43B1H24_03750674002..674085 [+], 8423S rRNA methylase leader peptide
44B1H24_03755674210..674947 [+], 73823S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)AR 
45B1H24_03760675093..675377 [+], 285topoisomerase
46B1H24_03765675550..676404 [+], 855chromosome partitioning protein ParA
47B1H24_03770676496..676711 [+], 216peptide-binding protein
48B1H24_03775676729..677001 [+], 273epsilon antitoxin
49B1H24_03780677003..677161 [+], 159zeta-toxin (disrupted by aadK)
50B1H24_03785677213..677758 [+], 546hypothetical protein
51B1H24_03790677934..678800 [+], 867aminoglycoside 6-adenylyltransferase aadKAR 
52B1H24_03795678749..679075 [-], 327hypothetical protein
53B1H24_03800679072..679212 [-], 141exodeoxyribonuclease V subunit alpha
54B1H24_03805679413..680039 [+], 627zeta-toxin (disrupted by aadK)
55B1H24_03815680831..681838 [+], 1008hypothetical proteinT4CP 
56B1H24_03820681961..683652 [+], 1692recombinaseOrf11_p, T4SS component 
57B1H24_03825683716..684816 [+], 1101DNA primase
58B1H24_03830684844..685071 [+], 228hypothetical protein
59B1H24_03835685068..685457 [+], 390chemotaxis protein
60B1H24_03840685508..685798 [+], 291hypothetical protein
61B1H24_03845685868..686344 [+], 477transcriptional regulator
62B1H24_03850686344..687111 [+], 768toxin PezT
63B1H24_03855687148..689655 [+], 2508recombinase RecF
64B1H24_03860689825..690061 [-], 237hypothetical protein
65B1H24_03865689993..690355 [+], 363hypothetical protein
66B1H24_03870690358..690723 [+], 366MobC
67B1H24_03875690710..692593 [+], 1884relaxaseRelaxase, MOBP Family
68B1H24_03880692690..694063 [+], 1374peptidase S8
69B1H24_03885694104..694802 [+], 699DNA-binding response regulator, NisR
70B1H24_03890694780..696123 [+], 1344two-component sensor histidine kinase
71B1H24_03895696313..697014 [+], 702lantibiotic ABC transporter ATP-binding protein
72B1H24_03900697007..697744 [+], 738lantibiotic ABC transporter permease
73B1H24_03905697722..698408 [+], 687ABC transporter permease
74B1H24_03915698847..699563 [+], 717NsuI
75B1H24_03920699831..700235 [+], 405RNA polymerase subunit sigma-70
76B1H24_03925700740..702533 [+], 1794site-specific recombinase family protein
77B1H24_03930702639..702851 [+], 213hypothetical protein
78B1H24_03935702969..703706 [+], 738acid phosphatase/phosphotransferase
79B1H24_03940704027..704545 [+], 519ClbS/DfsB family four-helix bundle protein
80B1H24_03950705382..705711 [+], 330cell surface protein
 
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer
virulence  Gene may be involved in adaptative function

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins71Fasta
(1) Zhou K; Xie L; Han L; Guo X; Wang Y; Sun J (2017). ICESag37, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in Streptococcus agalactiae. Front Microbiol. 1.667361111. [PudMed:29051752]