ICEberg
I. Information of ICE
ICEberg ID409
Name ICESp1108 This ICE is derived from experimental literature
FamilyTn1806
OrganismStreptococcus pyogenes C1
Size (bp)45456
GC content [Genome] (%)31.07
Insertion site3' end of the rum gene
Functionspectinomycin, erythromycin, tetronasin resistance
Species that ICE can be transferred to-
Nucleotide SequenceFR691054 (complete ICE sequence in this GenBank file)
Replicon-
Coordinates1694..47149 
Putative oriT region -
Putative relaxase coordinates: 38857..40188; Gene: ORF32;  Family:  MOBP


II. ICE interaction with IME/CIME/

The interaction information of ICESp1108 is not available.



The graph information of ICESp1108 components from FR691054
Complete gene list of ICESp1108 from FR691054
#Gene Coordinates [+/-], size (bp) Product 
(GenBank annotation)
*Reannotation 
1rum332..1720 [+], 138923S rRNA m(5)U 1939 methyltransferase
2ORF11951..2586 [+], 636replication initiator protein
3ORF22583..3410 [+], 828DNA replication protein
4ORF33403..3888 [+], 486hypothetical protein
5ORF43885..4619 [+], 735phage antirepressor protein
6ORF54612..6408 [+], 1797TraG/TraD/VirD4 bacterial conjugation protein
7ORF66427..6702 [+], 276hypothetical protein
8ORF76814..7182 [+], 369hypothetical protein
9ORF87529..7822 [+], 294hypothetical protein
10ORF98045..8356 [+], 312hypothetical protein
11ORF108358..8573 [+], 216hypothetical protein
12ORF118584..9447 [+], 864hypothetical protein
13ORF129457..9747 [+], 291hypothetical protein
14ORF139749..10159 [+], 411bacitracin resistance protein
15ORF1410050..12470 [+], 2421type IV secretory pathway protein VirB4PrgJ, T4SS component 
16ORF1512478..15057 [+], 2580NlpC/P60 family proteinOrf14_Tn, T4SS component 
17ORF1615298..16881 [+], 1584amine oxidase
18ORF1716896..17756 [+], 861hypothetical protein
19ORF1818053..18256 [+], 204hypothetical protein
20ORF1918492..19232 [+], 741hypothetical protein
21ORF2019354..21087 [+], 1734DNA topoisomerase IA
22ORF2121080..22045 [+], 966C-5 cytosine specific DNA methylase
23ORF2222032..29675 [+], 7644superfamily II DNA/RNA helicase
24ORF2329719..30375 [+], 657hypothetical protein
25ORF2430927..31559 [+], 633transcriptional regulator, TetR family
26ORF2531644..32525 [+], 882tetronasin resistance ATP-binding protein
27ORF2632458..34164 [+], 1707tetronasin resistance transmembrane protein
28ORF2734745..34951 [-], 207hypothetical protein
29erm(TR)34898..35629 [+], 732erythromycin resistance methylaseAR 
30ORF2935846..36370 [+], 525spectinomycin phosphotransferase
31ORF3036416..36535 [+], 120hypothetical protein
32ORF3137228..38451 [+], 1224transposase IS116/IS110/IS902 family protein
33ORF3238857..40188 [-], 1332relaxase/mobilization proteinRelaxase, MOBP Family
34ORF3340190..40648 [-], 459hypothetical protein
35ORF3440717..41811 [-], 1095RhuM
36ORF3541792..42274 [-], 483cation transporter family protein
37ORF3642283..42831 [-], 549Zn-dependent peptidase
38ORF3742840..43241 [-], 402trascriptional regulator Cro/CI family protein
39ORF3843376..43951 [+], 576hypothetical protein
40ORF3944221..44631 [+], 411RNA polymerase sigma-70 region 4
41ORF4045362..47149 [+], 1788putative recombinaseIntegrase 
42pnp47452..47850 [+], 399phosphorylase
 
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer
virulence  Gene may be involved in adaptative function

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins40Fasta
(1) Brenciani A; Tiberi E; Bacciaglia A; Petrelli D; Varaldo PE; Giovanetti E (2011). Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes. Antimicrob Agents Chemother. 55(5):2106-12. [PudMed:21343455] experimental
 
experimental experimental literature