ICEberg
I. Information of ICE
ICEberg ID187
Name 6180-RD.2 This is a predicted ICE derived from literature
Family10270-RD.2
OrganismStreptococcus pyogenes MGAS6180
Size (bp)37429
GC content [Genome] (%)35.13[38.35]
Insertion site-
FunctionVirulence: encodes cell surface anchored adhesins; R28.
Species that ICE can be transferred to-
Nucleotide SequenceCP000056 (complete ICE sequence in this genome)
Replicon chromosome (1897573 bp, BioProject:13887) [NC_007296]
Genome coordinates1284967..1322395 
Putative oriT region -
Putative relaxase coordinates: 1300598..1301839; Locus tag: M28_Spy1321;  Family:  MOBT


II. ICE interaction with IME/CIME/

The interaction information of 6180-RD.2 is not available.



The graph information of 6180-RD.2 components from CP000056
Complete gene list of 6180-RD.2 from CP000056
#Gene Coordinates [+/-], size (bp) Product 
(GenBank annotation)
*Reannotation 
1valS1280313..1282961 [-], 2649valyl-tRNA synthetase
2M28_Spy12971282963..1283547 [-], 585hypothetical protein
3M28_Spy12981283523..1283702 [-], 180ribosomal-protein-serine acetyltransferase
4M28_Spy12991284128..1284523 [-], 396hypothetical cytosolic protein
5M28_Spy13001284544..1284882 [-], 339hypothetical protein
6M28_Spy13011284867..1284983 [-], 117hypothetical protein
7M28_Spy13021284967..1286109 [-], 1143transposase
8M28_Spy13031286437..1287573 [-], 1137DNA integration/recombination/invertion proteinIntegrase 
9M28_Spy13041287623..1287955 [-], 333hypothetical protein
10M28_Spy13051288122..1288664 [-], 543hypothetical protein
11M28_Spy13061288887..1289648 [-], 762putative cell surface proteinPrgC, T4SS component 
12M28_Spy13071289673..1290230 [-], 558hypothetical exported protein
13M28_Spy13081290230..1291588 [-], 1359hypothetical exported protein
14M28_Spy13091291723..1291866 [+], 144hypothetical protein
15M28_Spy13101292034..1294349 [-], 2316membrane proteinYddG, T4SS component 
16M28_Spy13111294364..1296865 [-], 2502DNA segregation ATPase related proteinYddE, T4SS component 
17M28_Spy13121296886..1297296 [-], 411hypothetical proteinYddD, T4SS component 
18M28_Spy13131297299..1297568 [-], 270hypothetical protein
19M28_Spy13141297587..1298537 [-], 951hypothetical proteinYddB, T4SS component 
20M28_Spy13151298538..1299017 [-], 480hypothetical protein
21M28_Spy13161299025..1299276 [-], 252hypothetical protein
22M28_Spy13171299306..1299515 [-], 210hypothetical protein
23M28_Spy13181299559..1299831 [-], 273hypothetical protein
24M28_Spy13191300026..1300169 [-], 144transcriptional regulator, Cro/CI family
25M28_Spy13201300220..1300597 [-], 378hypothetical protein
26M28_Spy13211300598..1301839 [-], 1242transcriptional regulator, Cro/CI familyRelaxase, MOBT Family
27M28_Spy13221302151..1303860 [-], 1710FtsK/SpoIIIE familyYdcQ, T4SS component 
28M28_Spy13231303880..1304335 [-], 456hypothetical protein
29M28_Spy13241304338..1304643 [-], 306hypothetical protein
30M28_Spy13251304905..1308963 [-], 4059putative cell surface proteinPrgB, T4SS component 
31M28_Spy13261309133..1311373 [-], 2241putative cell surface proteinPrgA, T4SS component 
32M28_Spy13271311466..1311858 [-], 393hypothetical protein
33M28_Spy13281311982..1312422 [-], 441hypothetical protein
34M28_Spy13291312580..1313014 [-], 435transcriptional regulator, Cro/CI family
35M28_Spy13301313889..1314275 [+], 387transcriptional regulator, Cro/CI family
36M28_Spy13311314282..1314704 [+], 423hypothetical protein
37M28_Spy13321314769..1315125 [-], 357hypothetical exported protein
38M28_Spy13331315128..1315466 [-], 339hypothetical protein
39M28_Spy13341315463..1315756 [-], 294hypothetical protein
40M28_Spy13351315777..1315962 [+], 186transposase
41M28_Spy13361316468..1320961 [-], 4494R28 protein
42M28_Spy13371321190..1322395 [+], 1206transcriptional regulator, AraC family
43M28_Spy13381322913..1323665 [+], 753phospho-2-dehydro-3-deoxyheptonate aldolase
44aroB1323706..1324794 [+], 10893-dehydroquinate synthase
45M28_Spy13401325063..1325221 [-], 159hypothetical protein
46M28_Spy13411325229..1325534 [-], 306hypothetical cytosolic protein
47M28_Spy13421325536..1325874 [-], 339hypothetical cytosolic protein
48M28_Spy13431325927..1326682 [-], 756SAM-dependent methyltransferase
 
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins36Fasta
(1) Sitkiewicz I; Green NM; Guo N; Mereghetti L; Musser JM (2011). Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins. BMC Microbiol. 0.503472222. [PudMed:21457552] experimental
(2) Beres SB; Musser JM (2007). Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One. 2(8):e800. [PudMed:17726530]
 
experimental experimental literature